Submited on: 11 Dec 2015 03:47:53 PM GMT
Published on: 12 Dec 2015 08:53:08 AM GMT
 

  • What are the main claims of the paper and how important are they?

    NA


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    NA


  • Are the claims properly placed in the context of the previous literature?

    NA


  • Do the results support the claims? If not, what other evidence is required?

    NA


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    NA


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    NA


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    Yes,

    1.  First of all author need to provide representative picture for atherosclerotic plaque formation & prevention by drug treatments along with Illustration 10.

    2. It is also important to author show HDL and LDL cholesterol measurement data that will explain reduction in total cholesterol are because of reduction in LDL OR HDL-cholesterol.

    3.  It would be helpful if author can explain the reduction in liver wt.?

    It’s because of reduction in hepatic TG or TC, author need to measure hepatic TG and TC.

    4. Author need to provide liver tissue gene expression analysis data of LDLR, PCSK9 and others genes involved in lipid synthesis and fatty acid oxidation.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    No


  • Other Comments:

    COMMENTS FOR THE AUTHOR:

    In this manuscript, Williams et al show that BSN723T Prevents Atherosclerosis and Weight Gain in ApoE Knockout Mice Fed a Western Diet. While I think the topic is interesting, I still have some concerns about the data:

    1. First of all author need to provide representative picture for atherosclerotic plaque formation & prevention by drug treatments along with Illustration 10.

    2. It is also important to author show HDL and LDL cholesterol measurement data that will explain reduction in total cholesterol are because of reduction in LDL OR HDL-cholesterol.

    3. It would be helpful if author can explain the reduction in liver wt.?
    It’s because of reduction in hepatic TG or TC, author need to measure hepatic TG and TC.
     
    4. Author need to provide liver tissue gene expression analysis data of LDLR, PCSK9 and others genes involved in lipid synthesis and fatty acid oxidation.

  • Competing interests:
    .
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I have published many paper in Atherosclerosis and Journal of Lipid research.

  • How to cite:  Singh A B.BSN723T Prevents Atherosclerosis and Weight Gain in ApoE Knockout Mice Fed a Western Diet[Review of the article 'BSN723T Prevents Atherosclerosis and Weight Gain in ApoE Knockout Mice Fed a Western Diet ' by Lodder R].WebmedCentral 2016;7(1):WMCRW003265
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