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Remodelling Through The Growth Plate- An Experimental Study In Rats
By Ms. Chrysi Tsiouri , Prof. Vasileios Papavasileiou
Submited on: 10 Sep 2010 02:51:43 PM GMT
Published on: 10 Sep 2010 04:08:20 PM GMT
 
A review of Remodelling through the growth plate
Posted by Dr. William Kent on 16 Jun 2011 04:29:37 PM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? No
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? No
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? No
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    Population: An experimental rat study investigating the response to surgically inflicted trauma on 56 laboratory rats.

     

    Intervention: Surgically inflicted fracture of the right femur under GA.

    4 fractures had intra-medullary K-wire fixation in a posterior position (the significance or reasons for this are not clearly explained).

    The selection or allocation process is not described nor is the physical characteristics or ages of the rats in each group. 

    14 rats excluded because of infection.

    Rats sacrificed at 48, 96 or 168 hours. The numbers in each group are not reported. Assuming equal numbers: (56 - 14)/3 = 14 in each group.

     

    Comparison: Healthy left femur of (?)the same rat.

     

    Outcome: An objective (DNA/mg) but surrogate marker of bone remodelling and cell proliferation was used. The statistical methods used are not described (only the statistical package) and raw data is not presented, so the reader is unable to check if the data supports the conclusions.

     

    Reducing bias and confounding: It is not described in the text if strategies to reduce bias such as blinding or randomisation were used. The experimental groups were small and a substantial number were lost to follow-up. It is worrying that despite aseptic technique 25% of the subjects were lost to follow-up because of infection.

     

    Evaluation: The effect size of the experiment cannot be calculated and neither can the significance of the findings be checked because of the lack of data presented. Tables of subject characteristics and data should be included. The experimental process appears sound but further detail or referencing of methods is required for the experiment to be replicated. For example how was the magnitude of the injury standardised across all subjects? Greater detail and clarity in the methodology is required. This is an emotive topic (using rats and sacrificing them in the name of science) IF it is to be justified then the data and outcomes produced must be valid. The quality of this paper is let down by incomplete reporting, also the relevance and generalisability of the results to human bone and non-experimental injuries is unknown.

  • Competing interests:
    No competing interests.
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    Foundation trainee in orthopaedics

  • How to cite:  Kent W .A review of Remodelling through the growth plate[Review of the article 'Remodelling Through The Growth Plate- An Experimental Study In Rats ' by Papavasileiou V].WebmedCentral 2010;2(6):WMCRW00824
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Remodelling through the growth plate - an experimental study in rats
Posted by Mr. Frank N Xypnitos on 01 Dec 2010 02:13:37 AM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    I had the pleasure to review the article entitled "Remodelling through the growth plate - an experimental study in rats". In the present study a substantial amount of work has been done. The purpose of this study was to measure the cellular activity in different parts of the growth plate cells after fracture. The authors have conducted a very well organised experimental protocol and their results along with the educative illustrations, are soundly supporting their final conclusion. The authors conclude that the growth plate alters its activity so as to remodel the angulation of the healing fracture. The information provided is quite interesting and innovative, especially for the orthopaedic surgeons dealing with traumatic conditions.

  • Competing interests:
    No competing interest(s)
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    No research experience in this specific area of science.

  • How to cite:  Xypnitos F N.Remodelling through the growth plate - an experimental study in rats[Review of the article 'Remodelling Through The Growth Plate- An Experimental Study In Rats ' by Papavasileiou V].WebmedCentral 2010;1(12):WMCRW00185
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The response of the growth plate to trauma
Posted by Dr. Athanasios Papavasiliou on 13 Oct 2010 07:29:58 AM GMT

  • Other Comments: I would like to congratulate the authors on their work. The paper provides significant information on the function of the growth plate post trauma and on its role on remodeling. It also has great clinical applications on the treatmant of an immature skeleton.
  • Competing interests:
    No
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    None
  • Experience and credentials in the specific area of science:
    My PhD was based on the study of the growth plate
  • How to cite:  Papavasiliou A .The response of the growth plate to trauma[Review of the article 'Remodelling Through The Growth Plate- An Experimental Study In Rats ' by Papavasileiou V].WebmedCentral 2010;1(10):WMCRW0067
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