Submited on: 07 Nov 2011 04:51:27 PM GMT
Published on: 08 Nov 2011 03:40:11 PM GMT

Dear Colleagues, Reviewers,

This manuscript is the final revision of a case report in which I was the open-label subject and author. Each time I tested the effects by timing a 15K distance trail run on the same course, as the control-subject, I required my resting heart rate to be within 7-bpm of low resting heart rate (51-bpm). At the finish of each 15K timed run, heart rate ranged from 156-164 (105-110%) based on the Karvonnen Formula 220-age-years=149bpm maximum heart rate. During the first 90-day period, I was able to time 12-each 15K runs on the same course, During the second 90-day period, I was able to time 8-each 15K runs on the same course. Then I did a 14-day washout prior to timing a final 15K run to determine the effect if any of oral dosed Coenzyme Q10 on performances previously recorded. I submit this protocol is not conclusive, but it is sufficient to beg the questionto state more like timed trials inserting placebo and double blind protocols with men and women runners of a wide age-range may contribute to a responsible conclusion.

Bill Misner PhD