Submited on: 27 Sep 2012 01:21:44 AM GMT
Published on: 27 Sep 2012 07:37:53 PM GMT
Comment to Dr. Pascal F. Durrenberger
Posted by Dr. Akio Hiura on 20 Dec 2012 10:43:49 AM GMT

Our review is not overlap with Inoue's review (Microglia and intractable chronic pain, GLIA 61: 55-61, 2013). They reported the relationship between expression of P2X or Y receptors in microglia and neuropathic pain. Particullary, they argued that over expression of P2X4R on microglial cells enhanced by chemokine CCL2 released from the primary afferent central terminals after peripheral nerve injury may be crucial for microglial cells hyper-responsive to extracellular ATP, underlying for sustenance of neuropathic pain.  They highlighted the increasing evidences that spinal microglia control the hyperexcitability and pathogenesis of neuropathic pain, with a specific focus on microglial purinergic signaling. In our review, we speculated that the thermo TRP channels (TRPV1, TRPA1, TRPM8) could not sense neuropathic pain by themselves without close interactions between glial cells, immune cells and TRP channels. Also, we proposed a possible existence of noxious heat sensor other than thermo-TRP channels, TRPV1, TRPA1 and TRPM8. Thus, our review is never overlap with Inoue's review.