Case Report

By Dr. Amam Mohamed , Dr. Adil Nfifakh , Dr. Mohammed Rahmani
Corresponding Author Dr. Amam Mohamed
Urologie "A" Chu Avicennes, - Morocco
Submitting Author Dr. Amam Mohamed
Other Authors Dr. Adil Nfifakh
urologie "A" chu avicennes , - Morocco

Dr. Mohammed Rahmani
urologie "A" chu avicennes , - Morocco


Cystitis Glandularis, Benign Tumor of Bladder, Hematuria

Mohamed A, Nfifakh A, Rahmani M. The Cystitis Glandularis : Report of 4 Cases. WebmedCentral UROLOGY 2012;3(5):WMC003432
doi: 10.9754/journal.wmc.2012.003432

This is an open-access article distributed under the terms of the Creative Commons Attribution License(CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Submitted on: 31 May 2012 10:12:20 AM GMT
Published on: 31 May 2012 07:06:50 PM GMT


The cystitis glandularis is a rare and benign tumor, usually asymptomatic and is favored by chronic irritation. It is sometimes associated with a pelvic lipomatosis. Its transformation into adenocarcinoma is exceptional and occurs in cases of persistent contributing factor. Clinically, the hematuria is the dominating symptom with a pollakiuria. The treatment is various, in function of the tumoral volume and the importance of the symptomatology. The tumoral resection and the histological examination are fundamental for the diagnosis. we report 4 cases of cystitis glandularis treated in our service.


The cystitis glandularis was described for the first time in 1761 by Morgani, it is a rare and benign tumor of the bladder, developed from the islets of Von Brunn (epithelial clusters included in the mucosal lamina propria). His clinical impact is less than 1%. It mainly affects men, with peak incidence in the age of 50 years. The lesion is usually asymptomatic and discovered in a prolonged inflammatory context. We report 4 cases of cystitis glandularis, we analyze the epidemiological, clinical, biological, pathological and therapeutic of this affection.

Case report

In the last 5 years we treated four patients with cystitis glandularis. They were all male and aged 28, 45, 47 and 50 years. The clinical symptomatology was dominated by hematuria and pollakiuria. The ultrasound showed the presence of an intravesical tissular formation in all patients, with hydronephrosis in 2 cases. A scanner performed confirms the presence of a bladder tumor. A TURB was performed, histological examination showed  glandular metaplasia of bladder. One patient had a cystectomy (very important tumor), the other three have benefited, after the total resection, from an endoscopic surveillance with a good outcome with a 4-years follow.


Several theories attempt to explain this glandular metaplasia;
One of them is the metaplasia theorie: glandular cystitis is the answer to a chronic irritation (lithiasis, urinary stasis, urinary tract infection, tumors, obstructions). When the lesions are symptomatic, two major modes of presentation are described: the first one where irritative symptoms predominate (1/3 of cases). The second one where a macroscopic hematuria predominates(2/3 of cases). The conventional radiology usually shows a trigonal  mass in the bladder. The Pelvic CT scan and MRI show, in addition to the trigonal tumor, a thickening of the vesical base associate to a pelvic lipomatosis. The cystoscopy show the  tumor and the pathological examination provides diagnostic certainty.The association or the transformation to a bladder adenocarcinoma is possible but rare, it is a result to a long time exposition to many unfavorable factors.The treatment of causative factor, when it is identified, is fundamental: using long-term antibiotics for infections, vesical lithotripsy for lithiasis.A surgical procedure can be used, as a total or partiel cystectomy or reimplantation of the uretera, if it's necessary.


We note that the cystitis glandularis is a rare affection with local malignity, and usually asymptomatic. The research and treatment of irritative cause is essential. Endoscopic resection is, in general, sufficient to control it. If the tumor is important and recurrent, sometimes we have to practice a surgical act  because of its functional impact and the accompanying metaplasia.


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1 review posted so far

Needs a lot of improvements
Posted by Dr. Ahmed F Kotb on 02 Jun 2012 01:46:59 PM GMT

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