My opinion

By Dr. Deepak Gupta , Dr. Shushovan Chakrabortty , Prof. David Edelman
Corresponding Author Dr. Deepak Gupta
Wayne State University, - United States of America
Submitting Author Dr. Deepak Gupta
Other Authors Dr. Shushovan Chakrabortty
Wayne State University, Anesthesiology, - United States of America

Prof. David Edelman
Wayne State University, Surgery, - United States of America


Colonoscopy, Prebiotics, Probiotics

Gupta D, Chakrabortty S, Edelman D. Colon Reparation After Colonoscopy. WebmedCentral GASTROENTEROLOGY 2022;13(2):WMC005771

This is an open-access article distributed under the terms of the Creative Commons Attribution License(CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Submitted on: 21 Feb 2022 01:11:23 AM GMT
Published on: 22 Feb 2022 04:26:31 AM GMT

My opinion

The science of biomes has continued to grow during the ongoing global pandemic. COVID-19 has affected our biomes. The use of protective gear limits the ability of biomes to replenish while the absence of social contact limits biomes’ diversity. Our eating habits (processed foods) have also changed as we have quarantined for extended periods of time. There is an ongoing balance between probiosis and antibiosis [1-4]. Perioperative and peripartum medicine should evolve and include consideration for the use of synbiotics (prebiotics plus probiotics [5-6]).


As Bowel Prep for colonoscopy must be altering our biomes [7], we are putting forth the following questions:

  • Should we first investigate patients’ colonic biomes’ diversity as deciphered from the irrigated and suctioned fluids during their colonoscopies?
  • Why have we not realized yet that even the fiber man, Dr Denis Burkitt [8], if alive today would talk not only about eating fiber to naturalize our stool production but also about how eating fiber feeds our hungry gut biomes to normalize our stool production?
  • Do we ever wonder about travelers’ constipation due to lost biomes just like we have been conscious about travelers’ diarrhea due to pathogens’ exposure?
  • Can we agree that probiotics without prebiotics may be dangerous as by not providing foods for the expanded biomes, we are just adding more populations of hungry biomes in vivo while prebiotics without probiotics may be wasted as by not having any biomes to feed, prebiotics will just pass ex vivo?
  • Must we always consider person’s immune system’s integrity when considering adding any biomes in the form of probiotics [9]?
  • Do we ever wonder whether our zealous focus on colonoscopy-based screening for early diagnosis of colon cancer has made us ignore even discussing about potentially preventative role of our dietary habits against colon cancer?
  • Are we ignoring our viromes (commensal virophages, bacteriophages and virions) in the wholesome perspective of our biomes’ mutualism when we limit our focus to only our microbiomes (commensal bacteria) [10-13]?
  • Are we permanently reshaping our nasal biomes with nasal decolonization in healthcare institutions?
  • Are we permanently reshaping our newborns' biomes by adding more broad-spectrum antibiotics for surgical site infections’ prophylaxis during cesarean sections thus worsening the interference in essential vertical transmission of maternal biomes to their newborns?
  • Are we going for the overkill when cleansing and preparing genital areas externally and internally (with povidone-iodine or chlorohexidine) not only during cesarean sections but also during spontaneous and induced vaginal deliveries?
  • Do we ever wonder whether as compared to communal bathing in stagnant pools or ponds, communal bathing in flowing rivers or seas [14-15] may come in handy to flood our whole bodies with commensal biomes especially If pandemic mitigation measures continue to persist even after the pandemic is over?
  • Will there be a futuristic role for auto-transplantation of suctioned irrigating fluids with patients’ colonic biomes therein before finishing their colonoscopies?





What happens before your colonoscopy?

  • You take bowel preparation solution that is needed to clear up your colonic contents for visualization of your colon during colonoscopy


What happens during your colonoscopy?

  • With irrigating water, your colon is further cleared of any remaining contents in your colonic lumen and mucus sticking to your colonic wall for better visualization of your colon during colonoscopy


What happens after your colonoscopy?

  • It takes weeks for your colon to replenish its contents


Which colonic contents are we talking about?

  • Your colon contains biomes which are essential for your health


What helps in replenishing these biomes?

  • Your ingestion of prebiotic foods which your colonic biomes need to feed on and your ingestion of fermented foods which enrich diversity of your colonic biomes.


Which are the common prebiotic foods?

  • Legumes, beans, peas, oats, bananas, berries, asparagus, garlic, onions are some prebiotic foods


Which are the common fermented (probiotic) foods?

  • Yogurt, kefir, pickled vegetables, sauerkraut, kimchi, natto are some fermented (probiotic) foods


What are the cost implications?

  • Although most of these foods can be cost-effectively prepared at home, they may be affordably bought at cheaper prices from local farmers’ markets


What are the options for those allergic to certain foods?

  • There are gluten-free and dairy-free options available as over-the-counter prebiotic and probiotic supplements


What are the options for immunocompromised?

  • Check with your physician managing your immunocompromised state regarding which prebiotics and fermented foods as well as which prebiotic and probiotic supplements are safe for you


Besides prebiotics and probiotics, what else needs to be done for colonic reparation?

  • As colonoscopy is about visualizing what’s in your colonic wall and to visualize better, what’s in your colonic lumen has to be drained out, thereafter colonic lumen is replenished by prebiotic foods and probiotic foods while colonic wall gets strengthened with sound sleep, regular exercise and stress busters


Summarily, although we envisage that the future endoscopists may consider investigating and exploring the safety of synbiotic (prebiotic plus probiotic) bowel preparation solutions to be routinely used prior to colonoscopy as well as evolving safe synbiotic (prebiotic plus probiotic) irrigating water solutions to be routinely used during colonoscopy, we as providers can make the case in the interim for bowel reparations with synbiotic foods post-colonoscopy after the currently prevalent use of non-synbiotic bowel preparation regimens and bowel irrigation regimens for and during colonoscopies.


  1. Surgical site infections and the microbiome: An updated perspective. urgical-site-infections-and-the-microbiome-an-updated-perspective/31F5C47102A03ED7DBB4CE78B1A3953F
  2. Babies Born by C-Section Have Different Gut Microbes Than Vaginally Delivered Infants. -born-c-section-found-have-different-gut-microbes-vaginally-delivered-infants-180973174/
  3. Antibiotics at birth and later antibiotic courses: effects on gut microbiota. -01494-7
  4. The influence of prenatal and intrapartum antibiotics on intestinal microbiota colonisation in infants: A systematic review. https://www.sciencedirect .com/science/article/pii/S0163445320302747
  5. Probiotics and prebiotics. ics-english-2017.pdf
  6. Probiotics and Prebiotics: What’s the Difference? rition/probiotics-and-prebiotics
  7. Does Colon Cleansing Wipe Out Our Gut Microbiome? html
  8. The Fibre Man: The Life Story of Dr Denis Burkitt. .com/Fibre-Man-Life-story-Dr-Denis-Burkitt/dp/0856485837
  9. Immunosuppression and probiotics: are they effective and safe?
  10. Symbiosis: The Art of Living Together. https://w
  11. The other microbiome.
  12. The human virome: assembly, composition and host interactions. -00536-5
  13. Defining the Human Microbiome. https://academic.oup .com/nutritionreviews/article/70/suppl_1/S38/1921538
  14. World’s Largest Mass Bathing Event Influences the Bacterial Communities of Godavari, a Holy River of India. /10.1007/s00248-018-1169-1
  15. Swimming in the sea completely changes the microbes on your skin. s-the-microbes-on-your-skin/
  16. Intestinal flora after colonoscopy: How to rebuild it. en/interesting-facts/intestinal-flora/colonoscopy/

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WebmedCentral Article: Colon Reparation After Colonoscopy

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