My opinion

By Dr. Deepak Gupta
Corresponding Author Dr. Deepak Gupta
Wayne State University, - United States of America
Submitting Author Dr. Deepak Gupta

Disease Evolution, Foods, Biome-Enriching, Biome-Depleting, Salt Sugar Fat

Gupta D. Maybe Disease-Evolution Is All About Foods Which Are Either Biome-Enriching Or Biome-Depleting. WebmedCentral CARDIOLOGY 2022;13(9):WMC005795

This is an open-access article distributed under the terms of the Creative Commons Attribution License(CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Submitted on: 25 Sep 2022 11:15:40 AM GMT
Published on: 28 Sep 2022 01:53:31 AM GMT

My opinion

Researchers are investigating prevalence of diseases in low- and middle-income countries (LMICs) to reshape health policy [1]. However, research data warrants an understanding how human diseases have been evolving to be rampantly prevalent amongst rich-educated in high-income countries (HICs) thence rich-educated in LMICs thence poor-uneducated in HICs and finally poor-uneducated in LMICs with expected reversal of this rampant prevalence in the same order. Fault is often found with foods [2]. However, the question is why humans cannot resist salt, sugar and fat (SSF) [3]. Evolution can answer that [4]. Physiologically essential SSF were scarcely and rarely available during our prehistory. Nature forced fasting on our ancestors who had to feast on SSF whenever available for short spans of time. Consequently, only those ancestral genes survived whose vehicles (ancestral bodies) tolerated feasting on SSF because ancestors whose genes were intolerant to SSF feasting perished before reproducing in absence of essential SSF. However, things went overboard when humans evolved artificially-produced SSF overabundance. Now, current disease-paradigm suggests that those whose taste buds can resist SSF feasting will outlive those whose cannot. This may force food-industrial complex to feed their bottom-lines with SSF-depleted foods. Interestingly, only time will tell whether artificially-induced SSF-scarcity will revive natural selection of descendants feasting on essential SSF. Herein, synbiotic foods correcting-enriching our multi-millennium-old symbiotic biomes and thus countering their ongoing rampant depletion by ultra-processed foods may play major role to either channelize scarce SSF or neutralize abundant SSF in our foods [5].


  1. Kirschbaum TK, Sudharsanan N, Manne-Goehler J, et al. The Association of Socioeconomic Status With Hypertension in 76 Low- and Middle-Income Countries. J Am Coll Cardiol. 2022;80:804-817.
  2. Pokharel Y, Karmacharya BM, Neupane D. Hypertension-A Silent Killer Without Global Bounds: What Next? J Am Coll Cardiol. 2022;80:818-820.
  3. Moss M. epilogue: “We’re Hooked on Inexpensive Food”. In: Moss M, editor. Salt Sugar Fat: How the Food Giants Hooked Us. 1st edition. New York, NY: Random House, 2013:331-348.
  4. Natterson-Horowitz B, Bowers K. Zoophoria: Getting High and Getting Clean. In: Natterson-Horowitz B, Bowers K, editors. Zoobiquity: What Animals Can Teach Us About Health and the Science of Healing. 1st edition. New York, NY: Knopf, 2012:87-108.
  5. Sonnenburg J, Sonnenburg E. What Is the Microbiota and Why Should I Care. In: Sonnenburg J, Sonnenburg E, editors. The Good Gut: Taking Control of Your Weight, Your Mood, and Your Long-term Health. 1st edition. New York, NY: Penguin Press, 2015:9-34.

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