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http://www.webmedcentral.com/images/Header_Logo.giftext/html2011-08-22T16:23:27+01:00http://www.webmedcentral.com/Dr. Purushottam SahHyperactive Vagus Syndrome Causing Hyperglycemia!
http://www.webmedcentral.com/article_view/2106
Background: This is a hypothesis based on an observation made by the author when he was a rotating intern in the department of internal medicine. It was observed by the author that some patients admitted in the ward with peptic ulcer disease had their blood sugar levels above normal and their blood sugar levels came down to be within normal limits with anticholinergics containing hyoscine. The author explains it through the hypothesis of Hyperactive Vagus Syndrome.Conclusion: In some people vagus nerve is hyperactive and causes peptic ulcer disease together with hyperglycemia. This hyperglycemia can be corrected with the use of anticholinergics drugs. This aspect needs further experimental exploration.
text/html2012-03-07T21:03:06+01:00http://www.webmedcentral.com/Dr. Ole-Jan IversenThe Autoantigen Pso p27 is Generated from SCCA Molecules in Psoriatic Plaques
http://www.webmedcentral.com/article_view/3142
Psoriasis is a chronic inflammatory skin disease with unknown etiology. Infiltration of inflammatory cells as the initial event in the development of new psoriatic plaques together with the defined inflamed areas of such lesions this argues for an immunological disease with a local production of a causal antigen.Pso p27 is a protein expressed in psoriatic plaques and is shown to participate in complement activating immune complexes in the skin lesions.Recently we suggested that the Pso p27 antigen most probably is generated from SCCA- molecules by digestion with highly specific endoproteases.In this communication we substantiate this relationship and postulate an intracellular generation of Pso p27 antigen from SCCA molecules.