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http://www.webmedcentral.com/images/Header_Logo.giftext/html2010-10-27T21:30:46+01:00http://www.webmedcentral.com/Dr. Amin Malik Shah Abdul MajidHepatic Cytochrome P450 4a Expression Level In A Rat Model Of Microvesicular Steatosis
http://www.webmedcentral.com/article_view/1087
Microvesicular steatosis in general plays an important role in the pathogenesis of drug, disease and alcohol induced liver damage. Such an event is manifested by the accumulation of lipid within the hepatocytes. Initial experiments conducted previously showed that short-term intake of diets containing Orotic acid (OA) produced rapid and extensive steatosis that follows a microvesicular distribution (Su, Sefton et al. 1999). The present study evaluated the hepatic cytochrome P450 4A expression level in a rat model of microvesicular steatosis that was marked by the intake of diets containing 1% of the Orotic acid for a time period of 21 days. The animals were sacrificed on the 22nd day and the hepatic microsomal P450 A4 protein level was quantitated using immunoblot analysis. The result of the investigation showed a significant induction of CYP 4A expression level in groups that were fed with diets containing the 1% OA. The CYP4A in the test group livers was found to have been up regulated by 53% when compared to the control group. text/html2011-07-08T17:37:52+01:00http://www.webmedcentral.com/Dr. Sourabh AggarwalLesions on Dorsum of Hand
http://www.webmedcentral.com/article_view/2015
A 60 year old man presented with complaints of bleeding gums and yellow eyes. He also had a history of end stage liver disease from chronic alcoholism. He had history of recurrent hepatic encephalopathy and recurrent ascites. On examination, we noticed lesions on dorsal aspect of middle finger of his right hand (Figure 1). It was non-tender and blanching in nature.
The lesion on the finger is Spider Angioma. They are superficial and tortuous arterioles and occur mainly on the face and upper torso. Rarely, it can be found on hand as shown in the picture. If blanched, it is possible to see the emptied veins refilling from the center. This filling from center to outwards is unique to spider angioma.