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2024-03-28T15:04:30+01:00webmedcentral logo
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http://www.webmedcentral.com/images/Header_Logo.giftext/html2015-12-12T08:53:08+01:00http://www.webmedcentral.com/Dr. Robert A LodderBSN723T Prevents Atherosclerosis and Weight Gain in ApoE Knockout Mice Fed a Western Diet
http://www.webmedcentral.com/article_view/5034
Objective: This study tests the hypothesis that BSN723T can prevent the development of hyperlipidemia and atherosclerosis in ApoE-/- knockout mice fed a Western (high fat, high cholesterol, and high sucrose) diet. BSN723T is a combination drug therapy consisting of D-tagatose and dihydromyricetin (BSN723).
Background: D-tagatose has an antihyperglycemic effect in animal and human studies and shows promise as a treatment for type 2 diabetes and obesity. Many claims regarding BSN723’s pharmacological activities have been made including anti-cancer, anti-diabetic, anti-hypertensive, anti-inflammatory, and anti-atherosclerotic effects. To our knowledge this is the first study that combines D-tagatose and BSN723 for the treatment of hyperlipidemia and the prevention of atherosclerosis.
Methods: ApoE-deficient mice were randomized into five groups with equivalent mean body weights. The mice were given the following diets for 8 weeks: Group 1 - Standard diet; Group 2 - Western diet; Group 3 - Western diet formulated with D-tagatose; Group 4 - Western diet formulated with BSN723; Group 5 - Western diet formulated with BSN723T. Mice were measured for weight gain, tissue and organ weights, total serum cholesterol and triglycerides and formation of atherosclerosis.
Results: The addition of D-tagatose, either alone or in combination with BSN723, prevented the increase in adipose tissue and weight gain brought on by the Western diet. Both D-tagatose and BSN723 alone reduced total cholesterol and the formation of atherosclerosis in the aorta compared to mice on the Western diet. Addition of BSN723 to D-tagatose (BSN723T) did not increase efficacy in prevention of increases in cholesterol or atherosclerosis compared to D-tagatose alone.
Conclusion: Addition of either D-tagatose or BSN723 alone to a Western diet prevented weight gain, increases in total serum cholesterol and triglycerides, and the formation of atherosclerosis. However, there was no additive or synergistic effect on the measured parameters with the combination BSN723T treatment.text/html2016-12-21T16:07:38+01:00http://www.webmedcentral.com/Dr. Robert A LodderBSN272 Prevents Western Diet-Induced Atherosclerosis and Excess Weight Gain in ApoE-/- Mice
http://www.webmedcentral.com/article_view/5246
Objective: The purpose of this study was to determine whether BSN272 could prevent the development of hyperlipidemia and atherosclerosis in ApoE-/- knockout mice fed a Western (high fat and cholesterol, high sugar) diet.
Background: BSN272 is a combination drug therapy consisting of D-tagatose and polydatin. D-tagatose has been studied for the treatment of diabetes for several years and has been shown to lower glycated hemoglobin (HbA1c), to reduce cholesterol and triglycerides, as well as prevent weight gain in animals and humans. Polydatin is an antioxidant that appears to promote lipid catabolism and evidence suggests it can reduce diet-induced dyslipidemia in animals.
Methods: ApoE-deficient mice were randomized to produce three groups with the same mean body weight. The mice were given the following diets for 16 weeks: Group 1 - standard control diet; Group 2 - Western diet (high fat, high cholesterol diet, high sucrose); Group 3 - Western diet formulated with BSN272. Mice were measured for weight gain, tissue and organ weights, total serum cholesterol and triglycerides and formation of aortic atherosclerosis.
Results: Treatment of ApoE-/- mice prevented weight gain and lowered total cholesterol compared to mice on a Western diet alone. The effectiveness of BSN272 in lowering cholesterol increased over the time course of the experiment, with cholesterol steadily decreasing over the 16 weeks of treatment. Mice treated with BSN272 also showed significantly lower triglycerides than mice on the standard diet or the Western diet. The addition of BSN272 to the Western diet prevented the formation of atherosclerotic plaques compared to Western diet alone.
Conclusion: BSN272 prevents the development of atherosclerosis, excess weight gain, and rise in total cholesterol and triglycerides in ApoE-/- mice induced by a Western diet.