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Abstract : Tyrosine kinases inhibitors (TKI) are small molecules that interfere with cell signalling and target selected malignancies. The concern associated with oral drugs is related to their low and unpredictable bioavailability. In the past years, several TKI have been introduced in oncology and the risk of serious drug-drug ..

Abstract: Malignant neoplasms of the mouth represent approximately 5% of all malignancies on human beings in the world. More than 90% of cancer cases that occur in the mouth are squamous cell carcinomas. Objective: To know the frequency of oral squamous cell carcinoma in the population of Volta Redonda , Rio de Janeiro, Brazil, ..

Abstract : Sertoli-leydig cell tumor (SCLT) is a rare ovarian tumor that usually occurs unilaterally. These tumors constitute less than 0.5% of ovarian tumors and are further categorized based on the degree of mitotic activity. We present the case report of a young woman with an SLCT along with different considerations of treatme..

Abstract : Post-traumatic Stress Disorder (PTSD) has been found in patients in a number of diseases. However, the recognition of symptoms and categorisation of the disorder is still controversial and not universally agreed amongst clinicians and researchers. This paper presents the debate and how the symptoms of PTSD may be usefu..

Abstract: Gangliogliomas are rare neoplasms, histologically defined by the presence of both atypical ganglion cells and neoplastic glial cells. Usually located in the supratentorial space, they occur frequently during childhood and adolescence. Clinical and radiological features of GGs are not specific and are very similar to th..

Abstract: Within a glioma tumor mass and even in established glioma cell lines, resides a sub-population of cells known as glioma stem cells. These cells are postulated to contribute significantly to the treatment resistance among patients, and in fact are responsible for tumor re-growth.  Furthermore, current therapies favorab..

My opinion: Memory and language deficits in patients receiving chemotherapy have been noted; however, the aetiology is unknown. Particularly in the treatment of breast cancer, confounding factors include hormone therapy, and stress and anxiety during treatment. There are inconsistencies among clinical researchers over the neuropsy..

Abstract: Ear synovial sarcoma is thus rare, to our knowledge, there has been only one reported case in English medical literature. Here we report a second case of a locally advanced synovial sarcoma affecting the inner ear in a thirty-year-old female managed by chemotherapy and radiotherapy. The objective of the present paper w..

Dermatomyositis: 51 year-old-man, without history of disease, who had smoked 40-pack years, presented ten months before his admission, with an erythematous and scaly eruption over the extensor surfaces of the metacarpophalangeal joints and digits, knees were also affected ( illustration 1). The diagnosis of dermatomyositis was establis..

Abstract : The Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (APA, 1994) was revised in 1994 to include the diagnosis of a life threatening illness as a traumatic stressor constituting Post Traumatic Stress Disorder (PTSD). This inclusion prompted further research into PTSD in survivors of cancer. Understandin..

Abstract : Post-traumatic Stress Disorder (PTSD) has been found in patients in a number of diseases. However, the recognition of symptoms and categorisation of the disorder is still controversial and not universally agreed amongst clinicians and researchers. This paper presents the debate and how the symptoms of PTSD may be usefu..