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Dr. Joseph Tang

Assistant Professor
Clark University
950 Main Street

Brief Biography:


2002       Ph.D. Biochemistry (minor in Pharmacy), University of Wisconsin-Madison, Madison, Wisconsin

1992       M.S. Organic Chemistry, National Taiwan University, Taipei, Taiwan.

1990       B.S. Chemistry and Biochemistry, Tamkang University, Taipei, Taiwan.

Peer-Reviewed Publications

  1. Tang, K.H., Tang, Y.J. and Blankenship, R.E. (2011) Carbon metabolism pathways in phototrophic bacteria and their broader evolutionary implications. Front. Microbio. 2, 165 (Corresponding author)
  2. Tang, K.H., Barry, K., Chertkov, O., Dalin, E., Han, C.S., Hauser, L.J., Honchak, B.M., Karbach, L.E., Lapidus, A., Larimer, F.W., Mikhailova, N., Pitluck, S., Pierson, B.K. and Blankenship, R.E. (2011) Complete genome sequence of the filamentous anoxygenic phototrophic bacterium Chloroflexus aurantiacus. BMC Genomics. 12, 334 (Featured article)
  3. Tang, K.H. and Blankenship, R.E (2011) Neutron and light scattering studies of light-harvesting photosynthetic antenna complexes. Photosynth. Res. In press.
  4. Tang, K.H., Zhu, Y., Urban, V.S., Collins, A.M., Biswas, P. and Blankenship, R.E. (2011) Temperature and ionic strength effects on the chlorosome light-harvesting antenna complex. Langmuir 27, 4816-4828
  5. Tang, K.H., Feng, X., Zhuang, W.Q., Alvarez-Cohen, L., Blankenship, R.E. and Tang, Y.J. (2010) Carbon flow of heliobacteria is more related to Clostridia than to the green sulfur bacteria. J. Biol. Chem. 285, 35104-35112 (Corresponding author)
  6. Feng, X., Tang, K.H., Blankenship, R.E. and Tang, Y.J. (2010) Metabolic flux analysis of the mixotrophic metabolisms in the green sulfur bacterium Chlorobaculum tepidum. J. Biol. Chem. 285, 39544-39550 (Contributed equally to the work)
  7. Tang, K.H. and Blankenship, R.E. (2010) Both forward and reverse TCA cycles operate in the green sulfur bacteria. J. Biol. Chem. 285, 35844-35854
  8. Tang, K.H., Urban, V.S., Wen, J. and Blankenship, R.E. (2010) SANS investigation of the photosynthetic machinery of Chloroflexus aurantiacus. Biophys. J. 99, 2398-2407
  9. Tang, K.H., Yue, H, and Blankenship, R.E. (2010) Energy metabolism of Heliobacterium modesticaldum during phototrophic and chemotrophic growth. BMC Microbiology 10, 150
  10. Tang, K.H., Feng, X., Tang, Y.J. and Blankenship, R.E. (2009) Carbohydrate metabolism and carbon fixation in Roseobacter denitrificans OCh114. PLoS One 4, e7233
  11. Tang, K.H., Wen, J., Li, X. and Blankenship, R.E. (2009) Role of the AcsF protein in Chloroflexus aurantiacus. J. Bacteriol. 191, 3580-3587
  12. Tang, K.H., Mansoorabadi, S., Reed, G.H. and Frey, P.A. (2009) Suicide inhibition and radical triplet intermediates in reactions of 4-thia-D- and 4-thia-L-lysine with lysine 5,6-aminomutase. Biochemistry 48, 8151-8160
  13. Maity, A., Hsieh, C.P., Huang, M.H., Chen, Y.H., Tang, K.H., Behshad, E., Frey, P.A. and Ke, S.C. (2009) Evidence for conformational movement and radical mechanism in the reaction of 4-thia-L-lysine with lysine 5,6-aminomutase. J. Phys. Chem. B, 113, 12161-12163
  14. Tang, K.H., Niebuhr, M., Tung, C.S., Chen, S.C., Chou, C.C. and Tsai, M.D. (2008) Mismatched dNTP incorporation by DNA polymerase β does not proceed via globally different conformational pathways. Nucleic Acids Res. 36, 2948-2957 (Faculty of 1000) (Corresponding author)
  15. Tang, K.H. and Tsai, M.D. (2008) Structure and Function of 2:1 DNA polymerase-DNA complexes. J. Cell Physiol. 216, 315-320
  16. Tang, K.H., Niebuhr, M., Aulabaugh, A. and Tsai, M.D. (2008) Solution structures of 2:1 and 1:1 DNA polymerase-DNA complexes probed by ultracentrifugation and small-angle x-ray scattering. Nucleic Acids Res. 36, 849-860
  17. Tang, K.H., Guo, H., Yi, W., Tsai, M.D. and Wong, G.P. (2007) Investigation of conformational states of Wzz and the Wzz•O-antigen complex under near-physiological conditions. Biochemistry 46, 11744-11752
  18. Showalter, A.K., Lamarche, B.J., Bakhtina, M., Su, M.I., Tang, K.H. and Tsai, M.D. (2006) Mechanistic comparison of high-fidelity and error-prone DNA polymerases and ligases involved in DNA repair. Chem. Rev. 106, 340-360
  19. Tang, K.H., Liao, F.Y. and Tsai, Y.M. (2005) The study of intramolecular tandem radical cyclizations of acylsilanes with radicalphiles attached on silicon. Tetrahedron 61, 2037-2045
  20. Karbstein, K., Tang, K.H. and Herschlag, D. (2004) A base triple in the Tetrahymena group I core affects the reaction equilibrium via a threshold effect. RNA 10, 1730-1739
  21. Berkovitch, F, Behshad, E., Tang, K.H., Enns, E.A., Frey, P.A. and Drennan, C.L. (2004) A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase. Proc Natl Acad Sci U S A 101, 15870-15875
  22. Tang, K.H., Casarez, A.D., Wu, W. and Frey, P.A. (2003) Kinetic and biochemical analysis of the mechanism of action of lysine 5,6-aminomutase. Arch Biochem. Biophys. 418, 49-54
  23. Tang, K.H., Harms, A. and Frey, P.A. (2002) Identification of a novel pyridoxal 5´-phosphate binding site in adenosylcobalamin-dependent lysine 5,6-aminomutase from Porphyromonas gingivalis. Biochemistry, 41, 8767-8776
  24. Tang, K.H., Chang, C.H. and Frey, P.A. (2001) Electron transfer in the substrate-dependent suicide inactivation of lysine 5,6-aminomutase. Biochemistry, 40, 5190-5199
  25. Jiaang, W.T., Lin, H.C., Tang, K.H., Chang, L.B. and Tsai, Y.M. (1999) The study of kinetics of intramolecular radical cyclizations of acylsilanes via the intramolecular competition method. J. Org. Chem. 64, 618-628
  26. Chang, S.Y., Jiaang, W.T., Cherng, C.D., Tang, K.H., Huang, C.H. and Tsai, Y.M. (1997) The scope and limitations of intramolecular radical cyclizations of acylsilanes with alkyl, aryl, and vinyl radicals. J. Org. Chem. 62, 9089-9098
  27. Tsai, Y.M., Tang, K.H. and Jiaang, W.T. (1996) Group transfer from silicon to carbon via tandem radical cyclizations of acylsilanes. Tetrahedron Lett. 37, 7767-7770
  28. Tsai, Y.M., Tang, K.H. and Jiaang, W.T. (1993) Radical cyclizations of bromo acylsilanes and intramolecular trapping of the rearranged alpha-silyloxy radicals. Tetrahedron Lett. 34, 1303-1306

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