Brief Biography:
Education:
M.D./Ph.D., University of Cincinnati College of Medicine, Cincinnati, Ohio
Pediatric Residency, University of Texas-Houston Medical School, Houston, Texas
Pediatric Nephrology Fellowship, University of Texas-Houston Medical School, Houston, Texas
Publications
1. 2011 S.M. Herring, N. Gokul, M. Monita, R. Bell, E. Boerwinkle, Scott E. Wenderfer, M.C. Braun and P.A. Doris. The rat Immunoglobulin locus is associated with serum IgG levels and albuminuria. J Am Society Nephrology. 2011 May;22(5):881-9. PMID: 21454716
2. 2010 Scott E. Wenderfer, J.P. Samuel, and M.C. Braun. Acute Glomerulonephritis. In Pediatric Nephrology: A Handbook for Training Health Care Providers. Editors: D. Silverstein, U. Alon, J. Symons. In press.
3. 2010 Scott E. Wenderfer, R.D. Swinford, and M.C. Braun. C1q nephropathy in the pediatric population: pathology and pathogenesis. Pediatric Nephrology. 25(8):1385-96. PMID: 20180137
4. 2009 Scott E. Wenderfer, W.P.Dubinsky, M. Hernandez-Sanabria, M.C. Braun. Urine Proteome Analysis in Murine Nephrotoxic Serum Nephritis. Am J Nephrol. 30(5):450-458. PMID: 19776558
5. 2009 Scott E. Wenderfer, H. Wang, B. Ke, R.A. Wetsel, M.C. Braun. C3a Receptor Deficiency Accelerates the Onset of Renal Injury in the MRL/lpr Mouse. Molecular Immunology. 46(7): 1397-404. PMID: 19167760
6. 2008 Scott E Wenderfer, S. Stepkowski, M.C. Braun. Increased survival and reduced renal injury in MRL/lpr mice treated with a novel sphingosine-1-phosphate receptor agonist. Kidney International. 74(10): 1319–26. PMID: 18769369
7. 2007 Scott E. Wenderfer, K. Soimo, R.A. Wetsel, M.C. Braun. The Role of C4 Binding Protein in a Mouse Model of Inflammatory Kidney Disease. Arthritis Research & Therapy 9(5): R114. PMID: 17971229
8. 2007 Scott E. Wenderfer, R.D. Swinford, S Mauiyyedi, D.P. Witte, Michael C. Braun. Cytomegalovirus and Recurrent Idiopathic Membranoproliferative Glomerulonephritis Type 1: Cause or Consequence? Transplantation. 83(4): 523-4. PMID: 17318089
9. 2005 Scott E. Wenderfer, B. Ke, T.J. Hollman, H.Y. Lan, R.A. Wetsel, M.C. Braun. C5a Receptor Deficiency Attenuates T-cell Functions and Renal Disease in MRLlpr Mice. J Am Society Nephrology 16(12):3572-82. PMID: 16207826
10. 2004 Scott E. Wenderfer, J.J. Monaco. Exon Trapping for Positional Cloning and Fingerprinting. Methods in Molecular Biology: Bacterial Artificial Chromosomes: Functional Studies. Vol 256, Shaying Zhao, Marvin Stodolsky, Ed., Humana Press, Totowa, New Jersey. pp7-20. PMID: 15024156
11. 2000 Scott E. Wenderfer, J.P. Slack, T. Scott McCluskey, John J. Monaco. Identification of 40 Genes on a One Megabase Contig Around the IL-4 Cytokine Family Gene Cluster on Mouse Chromosome 11. Genomics 63(3):354-73. PMID: 10704283
12. 1998 A.G. Grandea, P.G. Comber, Scott E. Wenderfer, G. Schoenhals, K. Fruh, J.J. Monaco, Thomas Spies. Sequence, Linkage to H-2K, and Function of Mouse Tapasin in MHC Class I Assembly. Immunogenetics 48:260-5. PMID: 9716645
Oral Presentations
1. 2010 Gordon Research Conference: Antibody Biology & Engineering. Wenderfer. Immunoglobulin Receptors on Parenchymal Cells of the Kidney. Ventura, CA
2. 2007 American Society of Pediatric Nephrology Annual Meeting. Wenderfer, Stepkowski, Braun. Attenuation of Kidney Injury in a Mouse Model of Lupus Using a Selective Sphingosine-1-Phosphate Type 1 Receptor Agonist. Toronto, Ontario
3. 2006 American Society of Pediatric Nephrology Annual Meeting. Wenderfer, Ke, Wetsel, Braun. C3a Receptor Deficiency Is Associated with Exacerbation of Renal Disease and Increased Th-1 Cell Responses in MRLlpr Mice. San Francisco, CA
4. 2006 American Nephrology Nurses’ Association National Symposium. Wenderfer, Brannan, Smith, Tran and Swinford. Using Icodextrin to Improve Quality of Life and Clearance in a Pediatric Patient with Ultrafiltration Failure. Nashville, TN
5. 2006 University of Texas Health Science Center Pediatric Research Conference. Wenderfer, Braun. The Role of Complement in Adaptive Immunity and Autoimmune Nephritis. Houston, TX
6. 2005 University of Texas Health Science Center Pediatric Grand Rounds. Wenderfer. The Inflamed Kidney. Houston, TX
7. 2004 International Complement Workshop. Wenderfer, Ke, Lan, Braun. A Role for C5a in T-Cell Function and Renal Disease in MRL/lpr mice. Honalulu, HI
Peer Review Activities:
1. Reviewer for Kidney International, European Journal of Clinical Investigation,
Journal of Immunology
2. 2011: Ad hoc reviewer for Medical Research Council, United Kingdom. Clinician Scientist Fellowship.
3. 2011: Ad hoc reviewer for NIH National Center for Complementary and Alternative Medicine.
Invited Lectures
1. 2010: Pediatric Grand Rounds, Department of Pediatrics, University of Texas. Immune Complex Glomerulonephritis.
2. 2010: Rheumatology Grand Rounds, Department of Internal Medicine, University of Chicago. Lupus Nephritis Pathobiology.
3. 2010: Immunology Research Conference, Graduate School, University of Chicago. Parenchymal Receptors for Immune Complexes in the Kidney.
Honors
2011 Dean’s Teaching Excellence Award, UT Health Medical School
2011 Service Award, Harris County Hospital District
2010 Travel Award, Gordon Research Conference
2005 Travel Award, Society of Pediatric Research Annual Meeting
2004 Travel Fellowship, International Complement Workshop
2002 Travel Award, American Society of Pediatric Nephrology Annual Meeting
2002 Travel Award, American Society of Nephrology Annual Meeting
1996 – 1999 Wulsin Fellow, University of Cincinnati
1996 Academic Achievement Award, Department of Molecular Genetics, University of Cincinnati
1993 – 2001 U.C. Medical Science Scholar, University of Cincinnati
1990 – 1993 Edward W. Krause Scholar, University of Notre Dame
1990 Eagle Scout, Boy Scouts of America
Membership
2008 – present National Kidney Foundation
2004 – present American Society of Pediatric Nephrology
2004 – present American Society Nephrology
2003 – present American Association of Immunologists
Academic positions:
Primary Appointment: Assistant Professor, Renal Section, Texas Children's Hospital and Department of Pediatrics, Baylor College of Medicine, Houston TX (2011 - present)
Past Appointments: Assistant Professor of Pediatrics and Molecular Medicine, Division of Pediatric Nephrology and Hypertension, Institute of Molecular Medicine, and Graduate School of Biomedical Sciences, The University of Texas Health Science Center, Houston TX
Adjunct Appointments: Assistant Professor, Pediatrics, University of Texas M.D. Anderson Cancer Center
Research interests:
Dr. Wenderfer's academic research interests are in the mechanisms of immune complex disease in the kidney. Immune complexes are antigen-antibody complexes that form in numerous infectious or autoimmune diseases. Immune complex diseases such as serum sickness, viral hepatitis, essential mixed cryoglobulinemia, overwhelming sepsis, chronic infections, IgA nephropathy, and systemic lupus erythematosus (SLE) are important causes of renal morbidity and mortality in children and adults. Human biopsy studies and ESRD registry data demonstrate that IC are present in the kidneys of 45-65% of patients with glomerulopathies. Understanding the renal responses to immune complexes will aid in the management of patients with these diseases. This would reduce the burden of end stage renal disease and avoid the need for dialysis in a significant set of patients.
Dr. Wenderfer's clinical interests include glomerulonephritis, tubular and interstitial nephritis, and renal manifestations of rheumatic diseases such as lupus erythematosus.
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