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Prof. Mark Gorrell

Associate Professor
Centenary Institute
Locked Bag No. 6

Brief Biography:

Associate Professor Mark Gorrell heads the Molecular Hepatology Research Group at the Centenary Institute, which is closely affiliated with the University of Sydney and Royal Prince Alfred Hospital. Following his PhD from the Australian National University and postdoctoral training at the University of Melbourne, Australia, and Johns Hopkins University, Maryland, USA, Dr. Gorrell’s work has focused on elucidating structure - function relationships in dipeptidyl peptidase (DPP) IV and the related enzymes fibroblast activation protein, DPP8 and DPP9. His team uncovered mechanisms of protein binding and of enzyme activity in DPP4.


Dr. Gorrell holds patents on DPP8 and DPP9, which are crucial for evaluating the selectivity of DPP4 inhibitory compounds being used therapeutically in the management of type 2 diabetes mellitus. He has authored more than 105 publications, primarily on these dipeptidyl peptidases and liver disease pathogenesis, and is a member of the editorial boards of the World Journal of Gastroenterology and The Open Enzyme Inhibition Journal. Dr. Gorrell has been active in the Australia and New Zealand Cell and Developmental Biology Society including conference organization and is Treasurer of the International Proteolysis Society.


Academic positions:

Feb 2007 –

Associate Professor

            AW Morrow Gastroenterology and Liver Centre

Discipline of Medicine

Central Clinical School

            Sydney Medical School

            The University of Sydney


Nov 2007 –

Associate Faculty and Molecular Hepatology unit leader,

Liver Immunobiology Program

Centenary Institute, Sydney Medical School, University of Sydney


Research interests:

Understanding the functions of the prolyl oligopeptidase gene family, and the molecular pathogenesis of chronic liver disease, primarily assoicaiated with hepatitis C and type 2 diabetes.


What I think of the idea behind WebmedCentral:

Open access is a democratic and rapid means of disseminating peer-reviewed research.


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