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Dr. Arumugam Jayakumar

Research Scientist
The University of Texas M.D.Anderson Cancer Center
1515 Holcombe Blvd.

Brief Biography:

1. Bennett K, Callard R, Heywood W,  Harper J, Jayakumar A, Clayman GL, Di WL, Mills K. New Role for LEKTI in Skin Barrier Formation: Label-Free Quantitative Proteomic Identification of Caspase 14 as a Novel Target for the Protease Inhibitor LEKTI. J Proteome Res  2010 Aug 6;9(8):4289-94.

2. Kong LY, Gelbard A, Wei J, Reina-Ortiz C, Wang Y, Yang EC, Hailemichael Y, Fokt I, Jayakumar A, Qiao W, Fuller GN, Overwijk WW, Priebe W, Heimberger AB. Inhibition of p-STAT3 enhances IFN-α efficacy against metastatic melanoma in a murine model. Clin Cancer Res 2010 May 1; 16(9):2550-61.

3. Kupferman ME, Jayakumar A, Zhou G, Xie T, Dakak-Yazici Y, Zhao M, Ju J, Mandal M, Jasser S, Madden T, Myers JN, Priebe W. Therapeutic suppression of constitutive and inducible JAK/ STAT activation in head and neck squamous cell carcinoma. J Exp Ther Oncol. 2009; 8(2):117-27.

 4. Komatsu N, Saijoh K, Jayakumar A, Clayman GL, Tohyama M, Suga Y, Mizuno Y, Tsukamoto K, Taniuchi K, Takehara K, Diamandis EP. Correlation between SPINK5 gene mutations and clinical manifestations in Netherton syndrome patients. J Invest Dermatol. 2008 May; 128(5):1148-59.

5. Deraison C, Bonnart C, Lopez F, Besson C, Robinson R, Jayakumar A, Wagberg F, Brattsand M, Hachem JP, Leonardsson G, Hovnanian A. LEKTI fragments specifically inhibit KLK5, KLK7 and KLK14 and control desquamation through a pH-dependent interaction. Mol Biol Cell 2007 Sep; 18(9):3607-3619.

 6. Borgoño CA, Michael IP, Komatsu N, Jayakumar A, Kapadia R, Clayman GL, Sotiropoulou G, Diamandis EP. A potential role for multiple human tissue kallikrein serine proteases in epidermal desquamation. J Biol Chem. 2007 Feb 9; 282(6):3640-52.

7. Komatsu N, Saijoh K, Otsuki N, Kishi T, Micheal IP, Obiezu CV, Borgono CA, Takehara K, Jayakumar A, Wu HK, Clayman GL, Diamandis EP. Proteolytic processing of human growth hormone by multiple tissue kallikreins and regulation by the serine protease inhibitor Kazal-Type5 (SPINK5) protein, Clin Chim Acta. 2007 Feb; 377(1-2):228-36.

 8. Henderson YC, Frederick MJ, Jayakumar A, Choi Y, Wang MT, Kang Y, Evans R, Spring PM, Uesugi M, Clayman GL. Human LBP-32/MGR is a Repressor of the P450scc in Human Choriocarcinoma Cell Line JEG-3. Placenta. 2007 Feb-Mar; 28 (2-3):152-60.

 9. Hachem JP, Wagberg F, Schmuth M, Crumrine D, Lissens W, Jayakumar A, Houben E, Mauro TM, Leonardsson G, BrattsanM, Egelrud T, Roseeuw D, Clayman GL, Feingold KR, Williams ML, Elias PM. Serine Protease Activity And Residual LEKTI Expression Determine Phenotype In Netherton Syndrome. J Invest Dermatol. 2006 Jul; 126(7):1609-21.

10. Komatsu N, Suga Y, Saijoh K, Liu AC, Khan S, Mizuno Y, Ikeda S, Wu HK, Jayakumar A, Clayman GL, Shirasaki F, Takehara K, Diamandis EP. Elevated Human Tissue Kallikrein Levels in the Stratum Corneum and Serum of Peeling Skin Syndrome-Type B Patients Suggests an Over-Desquamation of Corneocytes. J Invest Dermatol. 2006 Oct; 126(10):2338-42.

11. Jayakumar A, Kang Y, Henderson Y, Mitsudo K, Liu X, Briggs K, Wang M, Frederick MJ, El-Naggar AK, Bebok Z, Clayman GL. Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distribution. Arch Biochem Biophys. 2005 Mar 1; 435(1):89-102.

12. Schechter NM, Choi EJ, Wang ZM, Hanakawa Y, Stanley JR, Kang Y, Clayman GL, Jayakumar A. Inhibition of Human Kallikreins 5 and 7 by the Serine Protease inhibitor, Lympho-Epithelial Kazal-Type Inhibitor (LEKTI). Biol Chem. 2005 Nov; 386(11):1173-84.

 13. Shellenberger TD, Mazumdar A, Henderson Y, Briggs K, Wang M, Chattopadhyay C, Jayakumar A, Frederick M, Clayman GL. Headpin: a serpin with endogenous and exogenous suppression of angiogenesis. Cancer Res. 2005 Dec 15; 65(24):11501-9.

 14. Jayakumar A, Cataltepe S, Kang Y, Frederick MJ, Mitsudo K, Henderson Y, Crawford SE, Silverman GA, Clayman GL. Production of serpins using baculovirus expression systems. Methods. 2004 Feb; 32(2):177-84.

15. Jayakumar A, Kang Y, Mitsudo K, Henderson Y, Frederick MJ, Wang M, El-Naggar AK, Marx UC, Briggs K, Clayman GL. Expression of LEKTI domains 6-9' in the baculovirus expression system: recombinant LEKTI domains 6-9' inhibit trypsin and subtilisin A.Protein Expr Purif. 2004 May; 35(1):93-01. 

 16. Shellenberger TD, Wang M, Gujrati M, Jayakumar A, Strieter RM, Burdick MD, Ioannides CG, Efferson CL, El-Naggar AK, Roberts D, Clayman GL, Frederick MJ. BRAK/CXCL14 is a potent inhibitor of angiogenesis and a chemotactic factor foimmature dendritic cells. Cancer Res. 2004 Nov 15; 64(22):8262-70. Erratum in: Cancer Res. 2004 Dec 15; 64(24):9230.

17. Raghunath M,  Tontsidou L,  Oji V,  Aufenvenne K,  Schurmeyer-Horst F, Jayakumar A,  Stander H,  Smolle J,  Clayman GL,  Traupe H . SPINK5 and Netherton syndrome: novel mutations, demonstration of missing LEKTI, and differential expression of transglutaminases. J Invest Dermatol. 2004 Sep; 123(3):474-83.

18. Jayakumar A, Kang Y, Frederick MJ, Pak SC, Henderson Y, Holton PR, Mitsudo K, Silverman GA, EL-Naggar AK, Bromme D, Clayman GL. Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis. Arch Biochem Biophys. 2003 Jan 15; 409(2):367-74.

19. Mitsudo K, Jayakumar A, Henderson Y, Frederick MJ, Kang Y, Wang M, El-Naggar AK, Clayman GL. Inhibition of serine proteinases plasmin, trypsin, subtilisin A, cathepsin G, and elastase by LEKTI: a kinetic analysis. Biochemistry. 2003 Apr 8; 42(13):3874-81.

20. Gonzalez HE,  Gujrati M,  Frederick M,  Henderson Y, Arumugam J,  Spring PW,  Mitsudo K,  Kim HW,  Clayman GL. Identification of 9 genes differentially expressed in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2003 Jul; 129(7):754-9.

21. Chirala SS, Jayakumar A,  Gu ZW,  Wakil SJ. Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3104-8.

22. Ranganna K,  Yatsu FM,  Hayes BE,  Milton SG, Jayakumar A. Butyrate inhibits proliferation-induced proliferating cell nuclear antigen expression (PCNA) in rat vascular smooth muscle cells. Mol Cell Biochem. 2000 Feb; 205(1-2):149-61.

23. Jayakumar A, Chirala SS, Wakil SJ. Human fatty acid synthase: assembling recombinant halves of the fatty acid synthase subunit protein reconstitutes enzyme activity. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23):12326-30.

24. Chirala SS, Huang WY, Jayakumar A, Sakai K, Wakil SJ. Animal fatty acid synthase: functional mapping and cloning and expression of the domain I constituent activities. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5588-93.

25. Jayakumar A, Huang WY, Raetz B, Chirala SS, Wakil SJ. Cloning and expression of the multifunctional human fatty acid synthase and its subdomains in Escherichia coli. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14509-14.

26. Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ. Human fatty acid synthase: properties and molecular cloning. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8695-9.

27. Abu-Elheiga L, Jayakumar A, Baldini A, Chirala SS, Wakil SJ. Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms. Proc Natl Acad Sci U S A. 1995 Apr 25; 92(9):4011-5.

28. Jayakumar A, Chirala SS, Chinault AC, Baldini A, Abu-Elheiga L, Wakil SJ. Isolation and chromosomal mapping of genomic clones encoding the human fatty acid synthase gene. Genomics. 1994 Sep 15; 23(2):420-4.

29. Mutirangura A, Jayakumar A,  Sutcliffe JS,  Nakao M,  McKinney MJ,  Buiting K,  Horsthemke B,  Beaudet AL,  Chinault AC,  Ledbetter DH. A complete YAC contig of the Prader-Willi/Angelman chromosome region (15q11-q13) and refined localization of the SNRPN gene. Genomics. 1993 Dec; 18(3):546-52.

30. Fabiny JM, Jayakumar A, Chinault AC, Barnes EM Jr. Ammonium transport in Escherichia coli: localization and nucleotide sequence of the amtA gene. J Gen Microbiol. 1991 Apr; 137(4):983-9.

31. Jayakumar A, Rudd KE, Fabiny JM, Barnes EM Jr. Localization of the Escherichia coli amtA gene to 95.8 minutes. J Bacteriol.1991 Mar; 173(5):1572-3.

32. Jayakumar A, Hwang SJ, Fabiny JM, Chinault AC, Barnes EM Jr. Isolation of an ammonium or methylammonium ion transport mutant of Escherichia coli and complementation by the cloned gene. J Bacteriol. 1989 Feb; 171(2):996-1001.

33. Jayakumar A, Hong JS, Barnes EM Jr. Feedback inhibition of ammonium (methylammonium) ion transport in Escherichia coli by glutamine and glutamine analogs. J Bacteriol.1987 Feb; 169(2):553-7.

34. Jayakumar A, Schulman I, MacNeil D, Barnes EM Jr. Role of the Escherichia coli glnALG operon in regulation of ammonium transport. J Bacteriol. 1986 Apr; 166(1):281-4.

35. Jayakumar A, Epstein W, Barnes EM Jr. Characterization of ammonium (methylammonium)/potassium antiport in Escherichia coli. J Biol Chem. (1985) Jun 25; 260(12):7528-32.

36. Jayakumar A, Cheng L, Liang CT, Sacktor B. Sodium gradient-dependent calcium uptake in renal basolateral membrane vesicles. Effect of parathyroid hormone. J Biol Chem. 1984 Sep 10; 259(17):10827-33.

37. Jayakumar A, Barnes EM Jr. The role of glutamine in regulation of ammonium transport in Azotobacter vinelandii. Arch Biochem Biophys. 1984 May 15; 231(1):95-101.

38. Jayakumar A, and Barnes EM Jr. A filtration method for measuring cellular uptake of [14C] methylamine and other highly permeant solutes. Anal Biochem. 1983 Dec; 135(2):475-8.

39. Barnes EMJr, Zimniak P, Jayakumar A. Role of glutamine synthetase in the uptake and metabolism of methylammonium by Azotobacter vinelandii. J Bacteriol. 1983 Nov; 156(2):752-7.

40. Khare S, Jayakumar A ,  Trivedi A ,  Kesavan PC ,  Prasad R . Radiation effects of membranes. I. Cellular permeability and cell survival. Radiat Res. 1982 May; 90(2):233-43.

41. Jayakumar A,  Singh M,  Verma RS,  Baquer NZ,  Prasad R . Characteristics of proline transport in the spheroplasts isolated from Candida albicans cells. Indian J Biochem Biophys. 1981 Jun; 18(3):206-10. 

42. Reddy TG, Jayakumar A, Mani R. Tolerance to anoxia in the scorpion, Heterometrus fulvipes.  Comp Physiol Ecol. 1980 Mar; 5(3):152-154.

43. Singh M, Jayakumar A, Prasad R. The effect of altered ergosterol content on the transport of various amino acids in Candida albicans. Biochim Biophys Acta. 1979 Jul 19; 555(1):42-55.

44. Singh M, Jayakumar A, Prasad R. Lipid composition and polyene antibiotic sensitivity in isolates of Candida albicans. Microbios. 1979; 24(95):7-17.

45. Jayakumar A, Singh M, Prasad R. An inducible proline transport system in Candida albicans. Biochim Biophys Acta. 1979 Sep 4; 556(1):144-50. 

46. Jayakumar A, Singh, M, Prasad R. Characteristics of proline transport in normal and starved cells of Candida albicans. Biochim Biophys Acta. 1978 Dec 19; 514(2):348-55.

47. Singh M, Jayakumar A, Prasad R. The effect of altered lipid composition on the transport of various amino acids in Candida albicans. Arch Biochem Biophys. 1978 Dec; 191(2):680-6.


Academic positions:

U.T.M.D. Anderson Cancer Center, Houston, TX

Research Scientist, Department of Experimental Therapeutics, 2007-present.

Assistant Professor, Department of Head & Neck Surgery, 2000-2006.

Baylor College of Medicine, Houston, TX

Assistant Professor, Department of Biochemistry and Molecular Biology, 1992-2000

Instructor, Department of Human and Molecular Genetics, 1990-1992

Research Associate, Department of Biochemistry and Molecular Biology, 1982-1990

NIH, Baltimore, MD   

Visiting Fellow, National Institute on Aging, 1980-1982


Research interests:

Cancer biology, tumor animal models, drug-discovery, small molecule inhibitors, serpins, membrane transport, lipid metabolism, recombinant protein expression, signaling pathways, ubiquitination and protein degradation.


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