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Formulation and Evaluation of Fast Dissolving Tablet of Gliclazide using Combination of Superdisintegrants
By Mrs. Rajeshree Panigrahi , Dr. Manas Bhowmik , Mrs. Saiprasanna Behera , Mr. Prasanta K Choudhury , Dr. K.a. Chowdary , Dr. Gitanjali Mishra
Submited on: 29 Feb 2012 11:08:12 AM GMT
Published on: 29 Feb 2012 02:49:25 PM GMT
 
Formulation and Evaluation of Fast Dissolving Tablet of Gliclazide using Combination of Superdisintegrants
Posted by Mr. Freddy Arce on 15 Nov 2016 03:11:49 PM GMT Reviewed by Interested Peers

  • What are the main claims of the paper and how important are they?

    Objective of this study was to formulate directly compressible fast dissolving tablets of Gliclazide with sufficient mechanical integrity, content uniformity, and acceptable palatability to assist patients of any age group for easy administration.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Yes


  • Are the claims properly placed in the context of the previous literature?

    Further development of the introduction would be good for the readers to get an understanding of the drug, what excipents are used and why. The introduction just seems to state definitions of things rather than show a background of the field and the utility of the formulation


  • Do the results support the claims? If not, what other evidence is required?

    More discussion should be placed on what are ideal values for certain variables that are being measured such as hardness, friability, water absorption, etc. and compare those to the results. All that is said is that the C4 formulation meets the official requirements.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    None that I have read


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    More discussion should be placed on how several experiments are set up such as water absorption. Also is an n=5 substantial enough to reliably say that a certain formultion has a better mouth feel than another?


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    Some stability studies in several RH would be nice to examine because for many of the fast-dissolving formulations moisture plays a major role. Furthermore, gliclazide itself is very poorly water soluble, has there been any bioavailablity studies conducted to see if one formulation is better than another? Or possibly work with other types of formulations to increase solubility.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    The discussion and conclusions should be elaborated more upon.


  • Other Comments:

    It would be easier for the reader to follow your data if in the paper certain tables and figures were referenced. This might be easier to do in the results section of your paper.

  • Competing interests:

  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    PhD student in a Pharmaceutical program

  • How to cite:  Arce F .Formulation and Evaluation of Fast Dissolving Tablet of Gliclazide using Combination of Superdisintegrants[Review of the article 'Formulation and Evaluation of Fast Dissolving Tablet of Gliclazide using Combination of Superdisintegrants ' by Mishra G].WebmedCentral 2016;7(11):WMCRW003313
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Formulation and Evaluation of Fast Dissolving Tablet of Gliclazide using Combination of Superdisintegrants
Posted by Dr. Khushwant S Yadav on 12 Mar 2012 03:36:40 PM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? No
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? No
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    Discussions could have been more stronger.

  • Competing interests:
    NO
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    NICE ATTEMPT HAS BEEN DONE

  • How to cite:  Yadav K S.Formulation and Evaluation of Fast Dissolving Tablet of Gliclazide using Combination of Superdisintegrants[Review of the article 'Formulation and Evaluation of Fast Dissolving Tablet of Gliclazide using Combination of Superdisintegrants ' by Mishra G].WebmedCentral 2016;3(3):WMCRW001580
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