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Mr. Paola Manduca

Professor Genetics
DIBIO-University of Genoa, Italy

Brief Biography:

Name: Paola Manduca
Born: January 8, 1946, Naples, Italy Address: Genetics, DISTAV
26.16132 Corso Europa, Genova, Italy
tel. and fax +39 3472540531- +39 10-3538240
Nationality: Italian


Academic positions:


1969: Biological Sciences 110 cum laude, University of Naples

Professina Career:

1. 1969-70: Research Assistant; Molecular Genetics Unit University of Edinburgh Scotland
2. 1970-71: Post-Doctoral Fellow, MRC Department of Epygenetics University of Edinburgh Scotland
3. 1971-87: Assistant Professor Institute of General Biology and Genetics University of Naples, Italy
4. 1987 -2004: Assistant Professor Genetics, Dept. of Oncology, Biology and Genetics
University of Genoa, Italy
5. 2004: Associate Professor sector BIO18 Confirmation
6. 1978-82: Course Genetics Bachelor of Science in Biological Sciences University of Naples, Italy
7. 1992-1995: Experimental Laboratory in Genetics II Bachelor Biological inScienze
University of Genoa, Italy
8. 1993 to 2004: Advanced Genetics II Bachelor of Science in Biological Sciences
University of Genoa, Italy
9. 2004: Course of Genetics, degree trienanle Module in the course of Developmental Biology and Genetics
10. 1999 - 2002: Professor of Biology and Ph.D. in Genetics
11. 2002: present PhD Professor of Genetics in Medicine and Biology of Differentiation Research at university
12. 1987: present Head of group head of the Laboratory of Genetics The Faculty of the University of Genoa SMFN Other positions
13. 1972-73 and 1975-76 Research Associate Division of Cell Biology leave for study
14. 1976-78: Graduate Student Department of Anthropology New School for Social
Research New York Master of Arts program Fellowship New York City Education Department
15. 1985-88: Visiting researcher Service of cell differentiation


Research interests:

Genetics, Molecular Genetics


Any other information:


1. Awny Naim, Hedaya Al Dalies, Mohammed El Balawi, Eman Salem, Kholud Al
Meziny, Raneem Al Shawwa, Roberto Minutolo and Paola Manduca
Article: Birth Defects in Gaza: Prevalence, Types, Familiarity and Correlation
with Environmental Factors Int. J. Environ. Res. Public Health 2012, 9(5), 1732-1747; doi:10.3390/ijerph9051732
Alaani S, Savabieasfahani M, Tafash M, Manduca P. Four polygamous families
with congenital birth defects from Fallujah, Iraq. Int J Environ Res Public Health.
2011 Jan;8(1):89-96. Epub 2010 Dec 31.
2. Visigalli D, Strangio A, Palmieri D, Manduca P. Hind limb unloading of mice
modulates gene expression at the protein and mRNA level in mesenchymal bone
cells. BMC Musculoskelet Disord. 2010 Jul 5;11:147.PMID: 20602768
3. Skaik S, Abu-Shaban N, Abu-Shaban N, Barbieri M, Barbieri M, Giani U,
Manduca P. Metals detected by ICP/MS in wound tissue of war injuries without
fragments in Gaza. BMC Int Health Hum Rights. 2010 Jun 25;10:17.
4. Palmieri D, Valli M, Viglio S, Ferrari N, Ledda B, Volta C, Manduca P.
Osteoblasts extracellular matrix induces vessel like structures through
glycosylated collagen I. Exp Cell Res. 2010 Mar 10;316(5):789-99. Epub 2009
Dec 16.
5. Visigalli D, Palmieri D, Strangio A, Astigiano S, Barbieri O, Casartelli G, Zicca
A, Manduca P.The carboxyl terminal trimer of procollagen I induces prometastatic
changes and vascularization in breast cancer cells xenografts. BMC
Cancer. 2009 Feb 18;9:59.
6. Manduca P, Castagnino A, Lombardini D, Marchisio S, Soldano S, Ulivi V,
Zanotti S, Garbi C, Ferrari N, Palmieri D. Role of MT1-MMP in the osteogenic
differentiation. Bone. 2009 Feb;44(2):251- 65.
7. Palmieri D, Astigiano S, Barbieri O, Ferrari N, Marchisio S, Ulivi V, Volta C,
Manduca P. Procollagen I COOH-terminal fragment induces VEGF-A and
CXCR4 expression in breast carcinoma cells. Exp Cell Res. 2008 Jul 1;314(11-
12):2289-98. Epub 2008 May 10.PMID: 18570923 [PubMed - indexed for
MEDLINE]Related citations
8. Manduca P, Marchisio S, Astigiano S, Zanotti S, Galmozzi F, Palermo C,
Palmieri D FMS*Calciumfluor specifically increases mRNA levels and induces
signaling via MAPK 42,44 and not FAK in differentiating rat osteoblasts. Cell
Biol Int. 2005 Aug;29(8):629-37.PMID: 16024262 [PubMed - indexed for
MEDLINE]Related citations
Palermo C, Manduca P, Gazzerro E, Foppiani L, Segat D, Barreca A. Potentiating
role of IGFBP-2 on IGF-II-stimulated alkaline phosphatase activity in
differentiating osteoblasts. Am J Physiol Endocrinol Metab. 2004 Apr;286(4)
9. Palmieri D, Poggi S, Ulivi V, Casartelli G, Manduca P. Pro-collagen I COOHterminal
trimer induces directional migration and metalloproteinases in breast
cancer cells. J Biol Chem. 2003 Feb 7;278(6):3639-47.
10. Ferrera D, Poggi S, Biassoni C, Dickson GR, Astigiano S, Barbieri O, Favre A,
Franzi AT, Strangio A, Federici A, Manduca P. Three-dimensional cultures of
normal human osteoblasts: proliferation and differentiation potential in vitro and
upon ectopic implantation in nude mice. Bone. 2002 May;30(5):718-25.
11. Palermo C, Manduca P. FMS*Calciumfluor increases alkaline phosphatase
expression during osteogenesis in vitro of tibia-derived rat osteoblasts by
activation of G alpha 0/G alpha i proteins. Boll Soc Ital Biol Sper. 2000 May-
12. Filanti C, Dickson GR, Di Martino D, Ulivi V, Sanguineti C, Romano P,
Palermo C, Manduca P. The expression of metalloproteinase-2, -9, and -14 and of
tissue inhibitors-1 and -2 is developmntally modulated during osteogenesis in
vitro, the mature osteoblastic phenotype expressing metalloproteinase-14. J Bone
Miner Res. 2000 Nov;15(11):2154-68.
13. Palmieri D, Camardella L, Ulivi V, Guasco G, Manduca P. Trimer carboxyl
propeptide of collagen I produced by mature osteoblasts is chemotactic for
endothelial cells.J Biol Chem. 2000 Oct 20;275(42):32658-63.
14. Palermo C, Filanti C, Poggi S, Manduca P Osteogenesis in vitro in rat tibiaderived
osteoblasts is promoted by the homeopathic preparation,
FMS*Calciumfluor. Cell Biol Int. 1999;23(1):31-40.
15. Festuccia C, Giunciuglio D, Guerra F, Villanova I, Angelucci A, Manduca P,
Teti A, Albini A, Bologna M. Osteoblasts modulate secretion of urokinase-type
plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9) in human
prostate cancer cells promoting migration and matrigel invasion. Oncol Res.
16. Manduca P, Palermo C, Caruso C, Brizzolara A, Sanguineti C, Filanti C, Zicca A.
Rat tibial osteoblasts III: propagation in vitro is accompanied by enhancement of
osteoblast phenotype. Bone. 1997 Jul;21(1):31-9.
17. Castoldi M, Pistone M, Caruso C, Puddu A, Filanti C, Piccini D, Tacchetti C,
Manduca P. Osteoblastic cells from rat long bone. II: Adhesion to substrata and
integrin expression in primary and propagated cultures. Cell Biol Int. 1997
18. Pistone M, Sanguineti C, Federici A, Sanguineti F, Defilippi P, Santolini F,
Querzé G, Marchisio PC, Manduca P. Integrin synthesis and utilization in
cultured human osteoblasts. Cell Biol Int. 1996 Jul;20(7):471-9.
19. MacNamara P, O'Shaughnessy C, Manduca P, Loughrey HC. Progesterone
receptors are expressed in human osteoblast-like cell lines and in primary human
osteoblast cultures. Calcif Tissue Int. 1995 Dec;57(6):436-41.
Giunciuglio D, Cai T, Filanti C, Manduca P, Albini A. Effect of osteoblast
supernatants on cancer cell migration and invasion. Cancer Lett. 1995 Oct
20. Stringa E, Filanti C, Giunciuglio D, Albini A, Manduca P. Osteoblastic cells
from rat long bone. I. Characterization of their differentiation in culture. Bone.
1995 Jun;16(6):663-70.
21. Puddu A, Filanti C, Zicca A, Cadoni A, Manduca P. Cultured tibial rat
osteoblasts: in vitro production and topography of osteonectin, biglycan and
decorin. Boll Soc Ital Biol Sper. 1995 Mar- Apr;71(3-4):91-7.
22. Manduca P, Pistone M, Sanguineti C, Lu K, Stringa E. Modulation of integrins
expression during human osteoblasts "in vitro" differentiation. Boll Soc Ital Biol
Sper. 1993 Nov;69(11):699-704.
23. Manduca P, Sanguineti C, Pistone M, Boccignone E, Sanguineti F, Santolini F,
Federici A. Differential expression of alkaline phosphatase in clones of human
osteoblast-like cells. J Bone Miner Res. 1993 Mar;8(3):291-300.
24. Descalzi Cancedda F, Gentili C, Manduca P, Cancedda R. Hypertrophic
chondrocytes undergo further differentiation in culture. J Cell Biol. 1992
25. Manduca P, Descalzi Cancedda F, Cancedda R. Chondrogenic differentiation in
chick embryo osteoblast cultures. Eur J Cell Biol. 1992 Apr;57(2):193-201.
26. Manduca P, Abelmoschi ML. Retinoic acid, hemin and hexamethylen
bisacetamide interference with "in vitro" differentiation of chick embryo
chondrocytes. Cell Biol Int Rep. 1992 Jan;16(1):73-82.
27. Manduca P, Descalzi Cancedda F, Tacchetti C, Quarto R, Fossa P, Cancedda R.
Synthesis and secretion of Ch 21 protein in embryonic chick skeletal tissues. Eur J
Cell Biol. 1989 Oct;50(1):154-61.
28. Descalzi Cancedda F, Manduca P, Tacchetti C, Fossa P, Quarto R, Cancedda R.
Developmentally regulated synthesis of a low molecular weight protein (Ch 21) by
differentiating chondrocytes. J Cell Biol. 1988 Dec;107(6 Pt 1):2455-63.
29. Manduca P, Castagnola P, Cancedda R. Developmentally regulated synthesis of a
low molecular weight protein (Ch 21) by differentiating chondrocytes. Dev Biol.
1988 Jan;125(1):234-6.
30. Foresti M, Gaudio L, Geraci G, Manduca P. Inhibition of dimethyl sulfoxide
induced erythropoietic differentiation of murine erythroleukemia cells in culture.
Cancer Res. 1986 Dec;46(12 Pt 1):6260-3.
31. Manduca P. Isolation and characterization of murine erythroleukemia cell
variants nonresponsive to hemin for the expression of globin genes. Somatic Cell
Genet. 1981 Jan;7(1):11-26.
32. Marin G, Manduca P. Synchronous replication of the parental chromosomes in a
Chinese hamster- mouse somatic hybrid. Exp Cell Res. 1972 Nov;75(1):290-3.


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