The paper claims that, how to acheive artificially, the natural enzymes. the author mentioned different methods reported by some research groups. the area of work is very innovative and new concept which needs future.

As this article is a review one. the author has discussed different approaches on this area, how people have published their work in this area.

Yes, but there is still some more trimming required. still some more explainatory data required to support the final evidence.

Further evidence is required. the recent publishings, especially. although the concept is new, much work has to be done. as this article is a review one, the article should cover the entire data available till now and compiled in proper way. if some more deep research findings included would be better.

No, there is no such explainations given.

As this is a review article, the author has collected information available till now, but the way how the work claiming its novelty has to be seen and some more success examples are needed.

Yes, there is a very much need of some more data, which will support the article. as the topic is new, getting new information is little bit difficult but not impossible! there is need of supporting information i.e., spectral characterization and data that confirmed the formation of artificial enzymes.

The concept is good, but the practical aspects have yet to be done, in order to make it much better. this article is worth for presenting as well.

This article needs revision of spelling mistakes, as there are much (typing errors) please correct the necessary. some sentences were taken as such from articles the author has quoted. so, if possible please try to rewrite those introductory sentences in a much skillfull representation, to grab the interest of readers while reading. the characterization and confirmation of artificial enzymes formation is very much needed.

NA