Submited on: 14 Sep 2012 01:33:48 PM GMT
Published on: 15 Sep 2012 05:26:38 PM GMT
A Novel Top Down Mechanism in Neocortex
Posted by Prof. Paul Nunez on 16 Sep 2012 02:00:16 PM GMT

  • What are the main claims of the paper and how important are they?

    This is a very innovative and speculative paper outlining a possible significant top down dynamic mechanism in neocortex. The proposed process is the small scale magnetic field produced by columnar scale currents across the cortex. Such magnetic field is proposed to have sufficient magnitude to influence (top down) the momentum of Ca+ ions.

  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.


  • Are the claims properly placed in the context of the previous literature?


  • Do the results support the claims? If not, what other evidence is required?

    The theory seems plausible.

  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    NA, this is a theoretical paper

  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes, as a far as I can tell

  • Other Comments:


  • Competing interests:
  • Invited by the author to review this article? :
  • Have you previously published on this or a similar topic?:
  • References:
  • Experience and credentials in the specific area of science:


  • How to cite:  Nunez P .A Novel Top Down Mechanism in Neocortex[Review of the article 'Influence of Macrocolumnar EEG on Ca Waves ' by Ingber L].WebmedCentral 2012;3(9):WMCRW002239
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