Research articles

By Dr. Siana Shtilionova
Corresponding Author Dr. Siana Shtilionova
Dermatology Venerology, MU Varna, - Bulgaria
Submitting Author Dr. Siana Shtilionova

Gonococcical, Non- and Gonococcical Urethritis, Moxifloxacin

Shtilionova S. A New Therapeutic Scheme in Non- and Gonococcical Urethritis with Moxifloxacin. WebmedCentral DERMATOLOGY 2011;2(11):WMC002508
doi: 10.9754/journal.wmc.2011.002508
Submitted on: 27 Nov 2011 05:07:56 PM GMT
Published on: 28 Nov 2011 05:22:07 PM GMT


Gonococcical and non-gonococcical urethritis are sex transmitted diseases in which treatment, dermatologists use different therapeutic scheme.
We offer a new one in which Moxifloxacin 400 mg / per day is used it is a chinolonic antibiotic with good bactericidic effect to gram-positiveve and gram-negative bacteria.
20 males (10 with gonococical urethritis and 10 with non-gonococcical urethritis) were treated with Moxifloxacin 400 mg /per day for 7 days.
Excellent results were observed in all 20 patients at the end of the treatment. Exudation stopped after the 3rd day.
No adverse events were observed during and after the end of the treatment.
Key word: Gonococcical, non-gonococcical urethritis, Moxifloxacin


Gonococcal and non-gonococcal urethritis are sexually transmitted diseases, which occur in women and men. Gonococcal urethritis are one of the most often encountered sexually transmitted diseases. According to data from the WHO 25 million new cases are diagnosed annually as the disease is ranked the 4-th place after trichomonasis, chlamidial infection and condyloma acuminatum.  
It can be caused by N. gonorrhoeae, as after an incubation period of 1.6 up to maximum of 14 /fourteen/ days, leads to the development of an acute gonococcal urethritis in men.
Infection in women proceeds asymptomatic and develops chronic gonococcal infection.    
The most common non-gonococcal urethritis are caused by chlamydias, mycoplasma and trichomonas vaginalis.   
There are different therapeutic schemes for treatment of gonococcal and non-gonococcal urethritis. One of the modern therapeutic agents is Moxifloxacin.  It is of the quinolones group with activity against a large number of gram-positive and gram-negative pathogens. The bactericidal action of Moxifloxacin results from inhibition of the two II DNA topoisomerases, gyrase and topoisomerase IV, necessary for the bacterial replication, transcription and recovery.
Moxifloxacin can be eliminated by plasma with final elimination half-life approximately 12 /twelve/ hours.
The purpose of our survey is to assess the therapeutic result of the implementation of a new scheme for treatment of gonococcal and non-gonococcal urethritis with Moxifloxacin (Avelox - 0,400 mg).


We treated 20 /twenty/ men with acute gonococcal urethritis and 10/ten/ with non-gonococcal urethritis, of which:
Chlamydian - 6 patients
Trichomonas - 3 patients
Mycoplasma - 1 patient
In all patients the executed scheme was Moxifloxacin - 400 mg. for a period of 7 /seven/ days. The control examinations were held after the completion of treatment and 1 /one/ week after that.
It was reporting the exudation, the symptoms of urethral discomfort (burning and urinary urgency).
All of the patients were tested for HIV, Syphilis, Hepatit B and C, the results were negative.
The partners of all patients were treated prophylactic with Moxifloxacin 0,400 mg per day 5 /five/ consecutive days.
The laboratory proof of the etiologic agent in gonococcal urethritis was microscopic and in non-gonococcal urethritis - PCR and microscopic.
The end of the treatment, in all infected (100%) the subjective symptoms (burning, urethral exudation), have been suspended after the 3-rd day from the beginning of the treatment.
One week after the completion of the therapeutic scheme urethral exudation was not registered in no one from the treated patients. In those of the patients with non-gonococcal urethritis an excellent result was achieved in 5 (83.3 %) of the patients. PCR was negative. In 1(16.7%) patient the result was recorded as very good, because of the availability of passing subjective symptoms from mild burning when urinating. In other sick with mycoplasma and trichomonas urethritis, the result was excellent, expressing the complete absence of subjective symptoms.
At the time of the treatment have not been reported adverse reactions in the two groups treated patients. The patients with non-gonococcal urethritis were traced one week after the completion of the healing scheme. Objective and subjective symptoms of the disease were not read. Control laboratory and microscopic tests were negative.


1. Moxifloxacin is a quinolone antibiotic with a good therapeutic effect on acute gonococcal and non-gonococcal urethritis, treating the objective and subjective symptoms for a short period of time - 3 /three/ days.
2. Moxifloxacin has a convenient for reception form: 1/one/ time daily 7/seven/ days.
3. During the reception according to the therapeutic scheme, no side effects are observed.
4. Moxifloxacin is an agent of treatment of acute gonococcal and non-gonococcal urethritis.


1. Carlin EM, Barton SE Azitromycin as the first line treatment of non gonococcal urethritis (NGU): a study of follow up rates, contact attendance and patients treatment preference Int. J STD AIDS 1996.
2. Jones RB New treatments for Chlamydia trachomatis Amn J Obstet Gynecol 1991
3. Ridgway GL Advances in the antimicrobial therapy of chlamydial genital infections 1998
4. Taylor- Robinson D The history of non-gonococcal urethritis. Sex transm Dis 1996
5. Taylor- Robinson D Furr PM Genital mycoplasma infections. Wien Klin Wochenschr 1997.

Source(s) of Funding


Competing Interests



This article has been downloaded from WebmedCentral. With our unique author driven post publication peer review, contents posted on this web portal do not undergo any prepublication peer or editorial review. It is completely the responsibility of the authors to ensure not only scientific and ethical standards of the manuscript but also its grammatical accuracy. Authors must ensure that they obtain all the necessary permissions before submitting any information that requires obtaining a consent or approval from a third party. Authors should also ensure not to submit any information which they do not have the copyright of or of which they have transferred the copyrights to a third party.
Contents on WebmedCentral are purely for biomedical researchers and scientists. They are not meant to cater to the needs of an individual patient. The web portal or any content(s) therein is neither designed to support, nor replace, the relationship that exists between a patient/site visitor and his/her physician. Your use of the WebmedCentral site and its contents is entirely at your own risk. We do not take any responsibility for any harm that you may suffer or inflict on a third person by following the contents of this website.

1 comment posted so far

Please use this functionality to flag objectionable, inappropriate, inaccurate, and offensive content to WebmedCentral Team and the authors.


Author Comments
0 comments posted so far


What is article Popularity?

Article popularity is calculated by considering the scores: age of the article
Popularity = (P - 1) / (T + 2)^1.5
P : points is the sum of individual scores, which includes article Views, Downloads, Reviews, Comments and their weightage

Scores   Weightage
Views Points X 1
Download Points X 2
Comment Points X 5
Review Points X 10
Points= sum(Views Points + Download Points + Comment Points + Review Points)
T : time since submission in hours.
P is subtracted by 1 to negate submitter's vote.
Age factor is (time since submission in hours plus two) to the power of 1.5.factor.

How Article Quality Works?

For each article Authors/Readers, Reviewers and WMC Editors can review/rate the articles. These ratings are used to determine Feedback Scores.

In most cases, article receive ratings in the range of 0 to 10. We calculate average of all the ratings and consider it as article quality.

Quality=Average(Authors/Readers Ratings + Reviewers Ratings + WMC Editor Ratings)