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Comparison of Thrombin Generation Assay (TGA) and Non-Activated Partial Thromboplastin Time (NAPTT) for the Assessment of Enhanced Procoagulant Activity in Immunoglobulin Solutions
Abstract: The recent revision of the European Pharmacopoeia stipulates that all intravenous immunoglobulin solutions must be investigated with respect to procoagulant activity. Accordingly, the manufacturing processes must be validated regarding the removal of such compounds, to ensure a minimized thromboembolic risk for patient..
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The Germ-soma Conflict Theory of Aging and Death: Obituary to the "Evolutionary Theories of Aging"
Abstract: Regarding aging, the scientific community persists in a state of collective schizophrenia. This state is owed to the so-called “evolutionary theories of aging”. According to these theories, aging, following the peri-/postreproductive decline of selection pressure, is posited to be haphazard, not selected fo..
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The Potential Usefulness of Pre and Post Operative Risk Group Stratification in Predicting PSA Failure after Radical Prostatectomy for Localised Prostate Cancer
Abstract: Background: There is no clear cut way of predicting exactly prior to radical prostatectomy which patients would subsequently develop Biochemical failure post operatively.Aims: To investigate the usefulness of Risk Group stratification based upon: pre-operative PSA, clinical staging and Gleason score assessment of prost..
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Is Your Journal Indexed in PubMed? Relevance of PubMed in Biomedical Scientific Literature Today
Introduction: The arrival and spread of internet has enabled development of better bibliographic scientific databases with significantly improved capacity for storage and retrieval. In recent years, electronic database searching has become the default mode of bio-medical information retrieval. The National Library of Medicine (NLM) ..
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An Overview of Changing Trends in Systemic Fungal Infections
Abstract : Background:Invasive mycoses are a significant and growing public health problem. The increasing use of invasive monitoring and aggressive therapeutic technologies in intensive care units has resulted in improved survival of individuals with life-threatening illnesses, but has also contributed to an increase in number o..
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Piracetam (2-Oxo-Pyrrolidone) Advance and Modulate Central Processing Reaction Time in Normal Healthy Volunteers: Randomized Experimental Study; Single Blind Clinical Trail
Abstract : The present study was designed to show the effect of piracetam (2-Oxo-Pyrrolidone) on simple reaction time. This study involved 30 healthy volunteers which were recruited from medical college students (20 males and 10 females) .The reaction time was measured by ruler dropper test method, and by this method we can deter..
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Assessment of Third Ventricle with MRI: Morphological Variations Among Different Gender and Age Group
Abstract : Objectives: The aim of the morphometric study was to examine the range in the normal size of the third ventricle in the North Indian population; males and in females living in Punjab and, assess the existence of its relationship with gender and age; and clinically correlate. Materials and Methods: MRI of 300 subjects l..
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Recurrent Fibrolipoma of the Left Thigh - A Case Report
Abstract : A 43 year old male presented with giant fibrolipoma of the left thigh, recurrent for the 4th time. On contrast CT & MRI the tumor had massive adipose and non adipose components and enhanced heterogene..
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Autoamputation of Congenital Hairy Polyp in Neonate with Stridor and Respiratory Failure
Abstract : Hairy polyp of the oronasopharynx is a rare developmental malformation. It is usually seen as a pedunculated tumor in the neonate. It is classified as a dermoid since it is derived from the ectoderm ..
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Life Expectancy and Comparative Mortality of Major League Baseball players, 1900-1999.
Abstract: Several studies have documented increased life expectancy and improved mortality for Major League Baseball players, but none has yet provided a complete analysis of baseball player mortality patterns ..
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Prosthetic Rehabilitation of Maxillofacial Trauma Patient - A Case Report
Abstract : Rehabilitation of maxillofacial trauma patients is a challenging task. The most common prosthetic treatment problem with such patients is, getting adequate retention, stability and support. The size a..
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The Cost-Effectiveness and Competency Untold - An Analysis of Medical Tourism in Kerala with reference to Allopathic Medicine
Abstract: The key benefits of medical tourism in the ‘God’s Own Country’ are relatively competitive prices, quality, timely and personal care. The article unveils the cost difference between Kerala and other cities and compares with the main competitors like US and Thailand. Primary concerns are quality care, which include..
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Importance of Sample Size Calculation in the Original Medical Research Articles from Developing Countries
Abstract : Sample size calculation is very important for medical research. Because medical data is with uncertainty and most of the studies deals with a small sample and infer about a big population. But most of the researchers from developing countries like Nepal are not aware about this and who aware are not able to use this ..
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Relevance of Post or Pre Peer Review Process Journals for the improvement of Medical Research in Nepal
Abstract : Despite valuable research going on in developing countries like Nepal and the large number of existing scientific journals, this information does not reach international visibility. Not only are such journals obscure, but they also perpetuate a vicious circle of inadequacy that may directly be damaging the local scienc..
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Unreamed Solid Locked Nailing in the Treatment of Compound Diaphyseal Fractures of Tibia
Abstract: This is a prospective study based on 30 cases of compound tibial diaphyseal fractures fulfilling our inclusion criteria and stabilised with primary unreamed solid AO tibial locked nailing with a follow up ranging from 6-18 months. Open fractures were classified as per Gustillo’s. Road traffic accidents were responsib..
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A Case of Bilateral Optic Neuritis
Abstract : A 22 year male patient presented with headache fever and vomiting since 3 days duration and was initial managed as a case of meningitis or suspected brain abscess. He developed painful blurred vision ..
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Advanced Breast Cancer with Cerb2 Over Expression - A case Report
Abstract : A 53year old female presented with advanced carcinoma of the right breast with clinically positive right axillary lymph node. Triple assessment was done. FNAC confirmed ductal cancer, mammography sh..
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Assessment of Anti-Inflammatory and Analgesic Activities of Callicarpa Macrophylla Vahl. Roots Extracts
Abstract: Callicarpa macrophylla, an indigenous plant of India, had been the plant of study for the current research work. Aqueous as well as ethanolic extracts of its roots(at two concentrations 200 & 400 mg/kg) were evaluated for its analgesic and anti-inflammatory potentials using tail immersion test and carrageenan paw edema..
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Randomisation and blinding in clinical trials
Abstract : High quality clinical trials are designed to reduce bias, to increase the confidence that the reader can place in the conclusions of the trial. This article evaluates the role of randomisation and blinding to prevent bias and how to best implement them in a trial...
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The Pharmacokinetics of Alcohol in Healthy Adults
Abstract : Alcohol is a commonly used drug that has many important health consequences. To understand its physiological effects and predict drug interactions it is important to understanding alcohol’s pharmacokinetics and the factors that influence it. A brief review of the absorption, distribution, metabolism, and excretion of..
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